Gene name:
Map2k5 (Mek5;Mkk5;Prkmk5) ;
Protein name:
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5;MAPKK 5) ;
Alternative:
MAPK/ERK kinase 5 (MEK 5) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI.
Function:
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Subcellular Location:
Isoform Alpha-2
Membrane
The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.
Protein Attributes:
50:
MLWLALGPFR | AMENQVLVIR | IKIPNSGAVD | WTVHSGPQLL | FRDVLDVIGQ |
100:
VLPEATTTAF | EYEDEDGDRI | TVRSDEEMKA | MLSYYYSTVM | EQQVNGQLIE |
150:
PLQIFPRACK | PPGERNIHGL | KVNTRAGPSQ | HTSPVVSDSL | PSNSLKKSSA |
200:
ELRKILANGQ | MNEQDIRYRD | TLGHGNGGTV | YKAYHVPSGK | ILAVKVILLD |
250:
ITLELQKQIM | SELEILYKCD | SSYIIGFYGA | FFVENRISIC | TEFMDGGSLD |
300:
VYRKIPEHVL | GRIAVAVVKG | LTYLWSLKIL | HRDVKPSNML | VNTSGQVKLC |
350:
DFGVSTQLVN | SIAKTYVGTN | AYMAPERISG | EQYGIHSDVW | SLGISFMELA |
400:
LGRFPYPQIQ | KNQGSLMPLQ | LLQCIVDEDS | PVLPLGEFSE | PFVHFITQCM |
448:
RKQPKERPAP | EELMGHPFIV | QFNDGNATVV | SMWVCRALEE | RRSQQGPP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Rat MAP kinase kinase 5
ELISA Kit for Rat MAP kinase kinase 5
ELISA Kit for Rat MAP kinase kinase 5
CLIA Kit for Rat MAP kinase kinase 5
CLIA Kit for Rat MAP kinase kinase 5
CLIA Kit for Rat MAP kinase kinase 5
Polyclonal Antibody for Rat MAP kinase kinase 5
Polyclonal Antibody for Rat MAP kinase kinase 5
Polyclonal Antibody for Rat MAP kinase kinase 5
Monoclonal Antibody for Rat MAP kinase kinase 5
Monoclonal Antibody for Rat MAP kinase kinase 5
Monoclonal Antibody for Rat MAP kinase kinase 5
Protein for Rat MAP kinase kinase 5
Protein for Rat MAP kinase kinase 5
Protein for Rat MAP kinase kinase 5
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1; ALPHA-2 AND BETA);FUNCTION;MUTAGENESIS
strain :
Sprague-Dawley .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-1)
tissue :
Lung .